منابع مشابه
The CULt of Caspase-8 Ubiquitination
Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
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Activation of initiator caspases is dependent on interacting proteins, and Ipaf [ICE (interleukin-1beta-converting enzyme)-protease activating factor] {NLRC4 [NLR (Nod-like receptor) family CARD (caspase activation and recruitment domain)-containing 4]} an inflammasome component, is involved in caspase 1 activation and apoptosis. Investigating the mechanisms of Ipaf activation, we found that th...
متن کاملThe cult of mediocrity.
Accessible online at: www.karger.com/pps In several European countries, research progress is hindered by insufficient funding, lack of competing opportunities and the control of special interest groups, which disregard scientific merit and clinical value [1]. In Europe, these groups tend to control the mechanisms of academic promotion and feel threatened by talented and independent researchers ...
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Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor. Ptc has been shown to be a dependence receptor, and as such triggers apoptosis in the absence of its ligand. This apoptosis induction occurs through the recruitment by the Ptc intracellular domain of a caspase-activating complex, which includes the adaptor proteins DRAL and TUCAN, and the apical caspase-9. We show here ...
متن کاملThe effects of indirect exposure of nanosilver on caspase-8 and caspase-9 levels in liver and brain of suckling rats
Objective(s): The adverse health effects of nanosilver (AgNp) on adult animal models have been well documented. However, data is scarce regarding the toxic effects of AgNp on sensitive developmental stages. The present study aimed to investigate the effects of maternal milk exposure to AgNp on apoptosis induction in the liver and brain of the offspring of rats. Materials and Methods: Lact...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.04.052